Recalling the future: Immunological memory toward unpredictable influenza viruses

M Auladell; X Jia; L Hensen; B Chua; A Fox; THO Nguyen; PC Doherty; K Kedzierska

Journal article

Recalling the future: Immunological memory toward unpredictable influenza viruses

M Auladell, X Jia, L Hensen, B Chua, A Fox, THO Nguyen, PC Doherty, K Kedzierska

Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2019

DOI: 10.3389/fimmu.2019.01400

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Abstract

Persistent and durable immunological memory forms the basis of any successful vaccination protocol. Generation of pre-existing memory B cell and T cell pools is thus the key for maintaining protective immunity to seasonal, pandemic and avian influenza viruses. Long-lived antibody secreting cells (ASCs) are responsible for maintaining antibody levels in peripheral blood. Generated with CD4+ T help after naïve B cell precursors encounter their cognate antigen, the linked processes of differentiation (including Ig class switching) and proliferation also give rise to memory B cells, which then can change rapidly to ASC status after subsequent influenza encounters. Given that influenza viruses ev..

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Awarded by National Health and Medical Research Council

Funding Acknowledgements

KK is supported by the National Health and Medical Research Council (NHMRC) Program Grant (ID 1071916) and the NHMRC Senior Research Fellowship (ID 1102792). AF is supported by the NHMRC Program Grant (ID 1103367). MA and LH are supported by the Melbourne International Research Scholarship (MIRS) and the Melbourne International Fee Remission Scholarship (MIFRS) from The University of Melbourne. XJ is supported by CSC-UoM joint scholarship from The University of Melbourne. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health.